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Disalvo Anibal

Disalvo Anibal

Universidad Nacional de Santiago del Estero, Argentina

Title: The interaction of nano-archeasomes with lung surfactant in monolayer biomimetic systems


Disalvo Anibal is a specialist in Biophysical Chemistry of Lipid Membranes. The interest of research is the role of water in the structural and functional properties of biomembranes applying infrared, fluorescence spectroscopies, electrochemical methods and analysis of kinetic and thermodynamics of surface phenomena in lipid monolayers both experimentally and theoretically. He is currently working as a full Professor of Physical Chemistry and Biophysical Chemistry, University Santiago del Estero, Argentina from 2011. He is Supervisor of 16 PhD Doctorandus from 1984 till now. He published 2 books, 20 chapters and more than 150 papers in international journals. He is a member of the following organizations: Research Career of National Research Council (CONICET), Argentina; Member “ad hoc” of the Academy of Science, Argentina; Editorial Board of Chemistry and Physics of Lipids


Archaeosomes (ARC) are lipid vesicles composed by polar archaeolipids (TPA) extracted from hyperhalopileachae bacteria. In an "in vivo" context, inhaled ARC must first interact with the pulmonary surfactants (PS) lining layer covering the internal surface of the alveolus. Interactions of ARCs with the PS film determine the subsequent retention and translocation of the inhaled ARC and hence their potential activity on target cells. As in the respiratory cycle, the surface pressure of the surfactant monolayer changes, interaction was measured at different initial surface pressures. The changes were pronounced at low surface pressure (10 mN/m), where ARCs produce a much more noticeable effect in comparison to than hydrogenated soy phosphatidylcholine liposomes (L). Moreover, ARC incorporation rate into the PS membrane was two-fold effective when they were added from the air phase above the monolayer in comparison to when they were injected in the aqueous subphase underneath it. This makes ARC excellent candidates for delivering drugs to the lungs as inhaled nanoliposomes since they appear to interact with the hydrophobic moiety of PS