Hsien Ting Chiu
National Tsing Hua University, Republic of China
Title: Albumin-gold nanorods based core-shell nanoplatforms for cancer theranostics
Biography
Biography: Hsien Ting Chiu
Abstract
Over the past two decades, the rapid development of albumin- and gold nanostructures-based nanoplatforms offer promising solutions to address numerous scientific difficulties in cancer research such as drug delivery, tumor targeting and cancer therapy. In this study, a hybrid system (NR@SA) was designed for theranostic nanomedicine through chemically cross-linking of serum albumin (SA) shell outside the core of gold nanorod (Au NR). A tremendous amount of anticancer drugs, doxorubicin (DOX) could also be encapsulated inside the SA shell via physical adsorption during the formation of NR@SA:DOX. Our results demonstrated that the SA shell exhibited a great impact on the photoacoustic signal generation, leading to a strong contrast enhancement in photoacoustic imaging of tumor cells. Delivered NR@SA:DOX with higher DOX loading exhibited greater killing efficacy while the photothermal effect induced by the near-infrared laser irradiation also greatly improved the therapeutic efficacy of DOX against tramp-C1 prostate carcinoma in vitro and in vivo. These findings suggest that the development of core-shell nanoplatform, NR@SA is highly promising as an integrated theranostic nanoagent for further clinical applications