Xunan Zhang
Harbin Institution of Technology, China
Title: Hierarchical release of liposomes with aqueous two phase system: A new strategy for long circulating liposomes
Biography
Biography: Xunan Zhang
Abstract
We discovered the unique release behavior of aqueous two phase system (ATPS) within liposomes, which might pave new revenue for long-circulating liposomes. ATPS is composed of PEG and dextran. The unique release behavior is based on the disproportional distribution of DOX in each polymer phase. The release time was prolonged 3 h more than regular liposomes. Lipid vesicles were fabricated by electro-formation and extrusion methods. Furthermore, cytotoxicity and localization in HeLa cells of nanoscale vesicles were estimated. The inhibition rate was twice than pure drug