Parth Malik
Central University of Gujarat, India
Title: Nanoemulsions as candidate vehicles for natural phenolic compound curcumin
Submitted Date: September 29, 2016
Biography
Mr. Parth Malik is presently working for his Ph.D. in the domain of biocompatible nanoemulsions for improving the structural efficacy of bioactive compound curcumin. He is a specialist in Nanobiotechnology and has papers is reputed Elsevier, Wiley Science and Hindawi Journals. He has also actively taught the subjects of Nanobiotechnology, Bioprocess Engineering and Genetic Engineering to graduate and post-graduate students
Abstract
Curcumin is a very well-known natural polyphenolic compound, prevalent as the major ingredient of the familiar spice turmeric. Numerous studies have established its interesting immunomodulatory attributes, ranging from those of anticancer, antioxidant, antidiabetic, anti-inflammatory and several others. However, the most crucial hurdle has been the poor bioavailability of this bioactive compound, which is because of its poor aqueous solubility. Realizing this, we prepared the nanoemulsions of cottonseed oil with cationic, anionic and nonionic surfactants as potential carriers of curcumin with an aim to augment its antioxidant ability. The prepared nanoemulsions were characterized via density, surface tension and viscosity measurement at 298.15, 303.15 and 308.15 K. The antioxidant efficacy of curcumin loaded nanoemulsions was screened via DPPH free radical scavenging assay, wherein an RSA of more than 90% was observed. The reduced surface tension and increased viscosities signified efficient curcumin dispersion, enabled via characteristic thermodynamic shift
Shima Vaezi
Islamic Azad University South Tehran Branch, Iran
Title: Preparation of alginate-poly (vinyl alcohol) nanocapsules containing curcumin oil as the core
Submitted Date: September 29, 2016
Biography
Shima Vaezi has fulfilled her Bachelor’s degree in Chemical Engineering from Azad University, Tehran in 2013. After that, she studied Master of Chemical Textile Engineering at Azad University, Tehran. She is researching on nanocapsules for drug delivery
Abstract
The “Nanocapsules†are called to those structures which have been formed from an external thin layer and an internal great space. This is known as core/shell structure. In present experimental test, the O/W nanoemulsion/solvent evaporation method has been used for production of nanoÂmedicine containing the turmeric oil. The main purpose of this research is to apply polymer alloy of alginat/poly (vinyl alcohol) as wall material in capsulation process of natural plant essential. In first step, blend of polymers were used in wall and it was formed by dissolving a certain amount of polymer of alginate and poly (vinyl alcohol) within water (concentration of 0:1, 0.25:0.75, 0.5:0.5, 0.75:0.25, 1:0 w/v). Later on, a certain amount of turmeric oil (concentration of 0.75%, 05%, 0.25% w/v) was dissolved within ethanol and then was added to the primary solution drop by drop. After that, a certain amount of Tween 80 as surfactant and also calcium chloride as crosslinking agent were added to final solvent. In next step, obtained solvent was subjected to sonication and after that it was evaporated by vacuum device. In this research, we investigated effect of various factors such as layer of polymer concentration changes, variant concentration of turmeric oil and variant time of sonication on the size of nanocapsules. Scanning electron microscope (SEM), Zetasizer device with dynamic light scattering (DLS) technique were used to investigate of morphology and size of nanocapsules. The results of (DLS) analyses have proven that the best combination percentage for structure of the polymer layer is alginate with concentration of 0.25% and Poly (vinyl alcohol) with concentration of 0.75%. Therefore, the optimum amount of used polymer in the wall and different concentration of turmeric oil as the core have been investigated. The results of DLS test have demonstrated that the optimum concentration of turmeric oil is 0.25% (w/v) within ethanol. Furthermore, the optimum duration of sonication just took around 45 minutes. As results, the size of nanocapsules has been obtained up to 50 nm, with the optimum amount of used polymer in the wall. Also, the size of produced nanocapsule has been obtained up to 91 nm in the optimum concentration of turmeric oil. Finally, 45 minutes sonication leads to production of 50 nm nanocapsules.
