Hanan Mohamed
Cairo University, Egypt
Title: Daily used nanoparticles increases the incidence of cancer
Biography
Biography: Hanan Mohamed
Abstract
Nanoparticles are widely used in a wide variety of applications due to their high stability, resistance, and photocatalytic properties. Titanium dioxide (TiO2) nanoparticles are commercially used in a variety of consumer products e.g., toothpastes, sunscreens, cosmetics, food products, medications and wastewater treatment, that increasing daily human exposure to them. Therefore, TiO2 nanoparticles persistence and its effect on cancer incidence were investigated in this study. Significant elevations in tail length, %DNA damage and tail moment by nano-TiO2 particles during the experimental period evidenced the persistence of DNA damage. This was further confirmed by the appearance of laddered fragmentized and smeared genomic DNA. Moreover, the incidence in p53 mutations was increased by increasing the experimental period in nano-TiO2 treated groups. All these could be attributed to the persisted titanium accumulation and no clearance with time. Conclusion: persisted accumulation and no clearance of nano-titanium after stopping exposure enhanced its toxicity and increases the incidence of cancer.
