Ahmet Alper Öztürk
Anadolu University, Turkey
Title: Preparation and characterization of dexketoprofen tromethamol loaded eudragit® RS 100 nanoparticles
Biography
Biography: Ahmet Alper Öztürk
Abstract
Nonsteroidal antiinflammatory drugs (NSAIDs) also called nonsteroidal antiinflammatory agents/analgesics (NSAIAs) or nonsteroidal antiinflammatory medicines (NSAIMs) are a class of drugs which provide analgesic (pain-killing) and antipyretic (fever-reducing) effects, and antiinflammatory effects in higher doses. The most prominent members of this group, aspirin, ibuprofen and naproxen are all available as over-the-counter drugs in most countries. Arylpropionic acids are a group of NSAIDs currently produced in the racemic form. Dexketoprofen tromethamol is the dextrorotatory enantiomer of ketoprofen formulated as tromethamine salt. Dexketoprofen tromethamol’s distribution half-life and elimination half-life are 0.35 and 1.65 hours, respectively. Eudragit polymers which are acrylic/metacrylic acid esters act as polyelectrolytes regulated by percentage of charged (quaternary ammonium) and non-ionized (ether) groups in their structures. Eudragit RS® 100 is a poly-(ethyl acrylate, methyl methacrylate, chloro trimethyl ammonium ethyl methacrylate) copolymer. It is insoluble at physiological pH values but undergoes swelling in water. Eudragit RS® 100 is commonly used for enteric coating of tablets and preparation of controlled-release drug forms and represents a prototype for dispersion of drugs. Polymeric nanoparticles prepared by spray-drying method and characterized for controlled oral delivery of dexketoprofen tromethamol was aimed in this study.
