Nekane Guarrotxena
INSTITUTE OF POLYMER SCIENCE AND TECHNOLOGY , Spain
Title: SERS-based femto-sensitive nanosensor for protein detection
Biography
Biography: Nekane Guarrotxena
Abstract
Highly sensitive technology allows the detection of analytical targets in one sample providing a rapid and accurate clinical diagnostic. Among the potential analytical techniques surface-enhanced Raman scattering (SERS) offers unique advantages such as ultrasensitive detection down low the deconvolution times, fingerprint vibrational information of the target molecules, and the possibility of performing the experiments even in complex biological samples. Surface plasmon resonance (SPR) refers to the collective oscillations of the conduction electrons in metallic nanostructures. This phenomenon can also concentrate the incident electromagnetic field leading to Raman signal amplification to be used in a surface enhanced Raman scattering based detection methodology. Here, we discuss the design strategies for nanostructures to plasmonically enhance optical sensing signals up to femtoMolar level, highlighting their applications as SERS-enhanced optical sensors in multiplexed protein detection. In fact, our strategy lies on the design of multicomponent nanostructures, which embody the sensitivity afforded by Surface Enhanced Raman Spectroscopy (SERS) nanostructures with the wide selectivity that is characteristic of antibodies.