Vural Bütün
1Eskisehir Osmangazi University, Turkey
Title: Stimuli-responsive microgel/liposome hybrid biomaterials for controlled and targeted drug release applications
Biography
Biography: Vural Bütün
Abstract
Medical nanotechnology is a growing science that has applications on various areas of drug target, delivery or release. Nano-sized particles provide a control on optimization of the therapeutic index of cancer drugs. Beyond this therapeutic functionality, nanoparticles modified with magnetic Fe3O4 have been designed to deliver multiple components and imaging agents, diagnostics and therapies. In this study, multi-responsive microgels, which were first introduced by our group in the literature, were used in order to control targeting and releasing properties of liposomes. Firstly, 5-fluorouracil (5FU), which is used clinically to treat breast, stomach and colon cancer, was loaded into liposomes in aqueous media. Then, a water-soluble monomer, namely 2-(N-morpholino) ethyl methacrylate, based multi-responsive microgel hosting 5FU loaded liposome system was synthesized. In the third stage, a hybrid system consisting of liposome-5FU loaded microgels was covered with magnetic-nanoparticles to provide them to get responsiveness to a magnetic field. Finally, the resulting hybrid system was used for in vitro studies as a drug carrier and controlled drug release system in phosphate buffer solution incubated at 37°C. All microgel, liposome and hybrid-nanoparticles were characterized by using dynamic light scattering instrument, zeta potentiometer and transmission electron microscopy. The release of 5FU from liposome-microgel hybrid system was analyzed using HPLC with ultraviolet spectrophotometer detector having a wavelength of 266 nm