Pegah Esmaeilzadeh
Martin Luther University Halle Wittenberg, Germany
Title: A Smart Cell Carrier Nanosystem made from Thiolated Polysaccharides
Biography
Biography: Pegah Esmaeilzadeh
Abstract
Mimicking the functions of macromolecules, nanotechnology approaches have made great efforts to synthesize adaptive and stimuli-responsive biointerfaces for new therapeutic functions in medical implants or supporters for tissue growth/regeneration. Here, we introduce a switchable medical coating system made of 5 bilayers of thiolated- chitosan and thiolated-chondroitin sulfate biopolymers. This synthesized foundation were structured by bottom-up layer by layer technique. The idea of this study is a new cyclical methodology that enables forward and reverse surface reconstructions of cell-adhesive properties of multilayers by switching from oxidation to reduction direction (Oxi-to- Re) [figure 1] and in opposite from reduction to oxidation direction (Re-to-Oxi). While the rearrangements of surface charge, content of free thiol-groups and wettability characteristics after cyclical manipulations were tested by zeta potential, UV–Vis, and water contact angle techniques, monitoring the human dermal fibroblast cell– coating interactions confirms the smart multifunctionality of this novel coating model towards switchable protein adsorption/desorption and cell attachment/detachment rules.